Ser Is Another Potential PKA Phosphorylation Target of Cdc25B in G2/M Transition of Fertilized Mouse
نویسندگان
چکیده
Jianying Xiao, Chao Liu, Junjie Hou, Cheng Cui, Didi Wu, Huiyu Fan, Xiaohan Sun, Jun Meng, Fuquan Yang, Enhua Wang , and Bingzhi Yu ** From the Institute of Pathology and Pathopysiology, Department of Biochemical and Molecular Biology, and **The Key Laboratory of Medical Cell Biology, Ministry of Education of China, China Medical University, Shenyang, Liaoning Province 110001, China, the Department of Biochemical and Molecular Biology, Liaoning Medial University, Jinzhou, Liaoning Province 121001, China, and the Proteomic Platform, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China
منابع مشابه
Ser 15 of WEE1B is a potential PKA phosphorylation target in G2/M transition in one-cell stage mouse embryos.
The WEE1 kinase family has been shown to be the major kinase family responsible for phosphorylating Tyr 15 on cyclin-dependent kinase 1 (CDK1). WEE1 homolog 2 (WEE2, also known as WEE1B) was first identified in Xenopus laevis and more recently in humans and mice, and is responsible for phosphorylating the CDK1 inhibitory site and maintaining meiotic arrest in oocytes. However, the mechanism by ...
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Cdc25 phosphatases play key roles in cell cycle progression by activating cyclin-dependent kinases. In human cells, cdc25 proteins are encoded by a multigene family, consisting of cdc25A, cdc25B and cdc25C. While cdc25A plays a crucial role at the G1/S phase transition, cdc25C is involved in the dephosphorylation and activation of the mitotic kinase, cdc2/cyclinB. In addition, cdc25C itself is ...
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Xenopus oocytes, which are arrested in G(2) of meiosis I, contain complexes of cyclin B-cdc2 (M phase-promoting factor) that are kept repressed by inhibitory phosphorylations on cdc2 at Thr-14 and Tyr-15. Progesterone induces a cytoplasmic signaling pathway that leads to activation of cdc25, the phosphatase that removes these phosphorylations, catalyzing entry into M phase. It has been known fo...
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CDC25B phosphatase plays a key role in controlling G2-M progression by dephosphorylating two inhibitory residues of CDC2 and also has been suggested to have an oncogenic property. In this study, we investigated the effect of CDC25B overexpression on radiation-induced G2-M arrest and radiation sensitivity in esophageal cancer cells. TE8-CDC25B, in which CDC25B was overexpressed under an inducibl...
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We evaluated the cytostatic effect of 6,7-di-O-acetyl-sinococuline (FK-3000) isolated from Stephania delavayi Diels. against breast carcinoma cell lines MDA-MB‑231 and MCF-7. FK-3000 suppressed CDC25B phosphorylation directly and indirectly via p38 MAPK phosphorylation. CDC25B dephosphorylation decreased levels of cyclin B and phospho-CDC-2, and ultimately induced cell cycle arrest at the G2/M ...
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